The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation.

نویسندگان

  • E Marbaix
  • I Kokorine
  • P Henriet
  • J Donnez
  • P J Courtoy
  • Y Eeckhout
چکیده

Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.

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عنوان ژورنال:
  • The Biochemical journal

دوره 305 ( Pt 3)  شماره 

صفحات  -

تاریخ انتشار 1995